The successful use of indigenous knowledge (IK) in development practice in rural Africa over the last couple of decades has proved to be elusive and disappointing. Using empirical field data from northern Malawi, this study suggests that the two key drivers for farmers in this area are household food security and the maintenance of soil fertility. Indigenous ways of knowing underpin the agricultural system which has been developed, rather than the adoption of more modern, ‘scientific’ ways, to deliver against these drivers. Such IKs, however, are deeply embedded in the economic, social and cultural environments in which they operate.